Role of subthalamic nucleus and pedunculopontine nucleus in gait and balance in humans
Identifieur interne : 000755 ( Main/Exploration ); précédent : 000754; suivant : 000756Role of subthalamic nucleus and pedunculopontine nucleus in gait and balance in humans
Auteurs : Adele Demain [France]Source :
Descripteurs français
- mix :
English descriptors
Abstract
The respective roles of basal ganglia (BG) and the mesencephalic locomotor region (MLR) in the postural control and locomotion are not clearly established in humans. In these circuits, the subthalamic nucleus (STN) and the pedunculopuntine nucleus (PPN), two interconnected structures, appear to be involved in the locomotor pattern control and postural maintenance. Indeed, in patients with Parkinson’s disease (PD), characterized by a progressive loss of dopaminergic neurons and representing a model of dysfunction of the BG, there are dysfunctions of STN activity that could cause braking of movement underlying motor block (freezing of gait-FOG). In the PPN, greater loss of cholinergic neurons is observed in PD patients with falls. In this research, we studied STN activity and the effects of modulating the PPN activity during the stages of gait initiation (GI) in patients with PD. We found a modulation of activity of the STN with synchronization in the alpha frequency band before the postural adjustments and the execution of step, with PPN coherence. Low frequency stimulation of the PPN improved postural control with no significant effect on the locomotion. These data suggest that the STN is involved in the preparation of GI and the PPN has a leading role in postural control in humans. In a second part, we examined the role of the cortex-basal ganglia-PPN circuit in FOG and falls in a non-parkinsonian elderly population and demonstrated a selective lesion of this circuit in these subjects. Taken together, these data support the pathophysiological hypothesis for the origin of abnormal gait and balance in patients with PD, with lesion and/or dysfunction of the cortex-BG-PPN.
Url:
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Hal, to step Corpus: 000975
- to stream Hal, to step Curation: 000975
- to stream Hal, to step Checkpoint: 000243
- to stream Main, to step Merge: 000758
- to stream Main, to step Curation: 000755
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Role of subthalamic nucleus and pedunculopontine nucleus in gait and balance in humans</title><title xml:lang="fr">Rôle du noyau sous-thalamique et du noyau pédonculopontin dans la marche et l'équilibre chez l'homme</title><author><name sortKey="Demain, Adele" sort="Demain, Adele" uniqKey="Demain A" first="Adele" last="Demain">Adele Demain</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-246044" status="VALID"> <idno type="RNSR">200918525B</idno> <orgName>Institut du Cerveau et de la Moëlle Epinière</orgName> <orgName type="acronym">ICM</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital 75651 Paris Cedex 13</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation name="UM75" active="#struct-93591" type="direct"></relation> <relation name="U1127" active="#struct-303623" type="direct"></relation> <relation active="#struct-353778" type="direct"></relation> <relation name="UMR7225" active="#struct-441569" type="direct"></relation> </listRelation><tutelles><tutelle name="UM75" active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName> <orgName type="acronym">UPMC</orgName> <desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.upmc.fr/</ref> </desc></org></tutelle><tutelle name="U1127" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc></org></tutelle><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc></org></tutelle><tutelle name="UMR7225" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">HAL</idno><idno type="RBID">Hal:tel-01372198</idno><idno type="halId">tel-01372198</idno><idno type="halUri">https://tel.archives-ouvertes.fr/tel-01372198</idno><idno type="url">https://tel.archives-ouvertes.fr/tel-01372198</idno><date when="2014-09-26">2014-09-26</date><idno type="wicri:Area/Hal/Corpus">000975</idno><idno type="wicri:Area/Hal/Curation">000975</idno><idno type="wicri:Area/Hal/Checkpoint">000243</idno><idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000243</idno><idno type="wicri:Area/Main/Merge">000758</idno><idno type="wicri:Area/Main/Curation">000755</idno><idno type="wicri:Area/Main/Exploration">000755</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Role of subthalamic nucleus and pedunculopontine nucleus in gait and balance in humans</title><title xml:lang="fr">Rôle du noyau sous-thalamique et du noyau pédonculopontin dans la marche et l'équilibre chez l'homme</title><author><name sortKey="Demain, Adele" sort="Demain, Adele" uniqKey="Demain A" first="Adele" last="Demain">Adele Demain</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-246044" status="VALID"> <idno type="RNSR">200918525B</idno> <orgName>Institut du Cerveau et de la Moëlle Epinière</orgName> <orgName type="acronym">ICM</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital 75651 Paris Cedex 13</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation name="UM75" active="#struct-93591" type="direct"></relation> <relation name="U1127" active="#struct-303623" type="direct"></relation> <relation active="#struct-353778" type="direct"></relation> <relation name="UMR7225" active="#struct-441569" type="direct"></relation> </listRelation><tutelles><tutelle name="UM75" active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName> <orgName type="acronym">UPMC</orgName> <desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.upmc.fr/</ref> </desc></org></tutelle><tutelle name="U1127" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc></org></tutelle><tutelle active="#struct-353778" type="direct"><org type="institution" xml:id="struct-353778" status="VALID"> <orgName>CHU Pitié-Salpêtrière [APHP]</orgName> <desc> <address> <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref> </desc></org></tutelle><tutelle name="UMR7225" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author></analytic></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Higher Level Gait Disorders</term><term>Subthalamic nucleus</term></keywords><keywords scheme="mix" xml:lang="fr"><term>Maladie de Parkinson</term><term>Noyau pédunculopontin</term><term>Noyau sous-Thalamique</term><term>Troubles de la marche et de l'équilibre</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The respective roles of basal ganglia (BG) and the mesencephalic locomotor region (MLR) in the postural control and locomotion are not clearly established in humans. In these circuits, the subthalamic nucleus (STN) and the pedunculopuntine nucleus (PPN), two interconnected structures, appear to be involved in the locomotor pattern control and postural maintenance. Indeed, in patients with Parkinson’s disease (PD), characterized by a progressive loss of dopaminergic neurons and representing a model of dysfunction of the BG, there are dysfunctions of STN activity that could cause braking of movement underlying motor block (freezing of gait-FOG). In the PPN, greater loss of cholinergic neurons is observed in PD patients with falls. In this research, we studied STN activity and the effects of modulating the PPN activity during the stages of gait initiation (GI) in patients with PD. We found a modulation of activity of the STN with synchronization in the alpha frequency band before the postural adjustments and the execution of step, with PPN coherence. Low frequency stimulation of the PPN improved postural control with no significant effect on the locomotion. These data suggest that the STN is involved in the preparation of GI and the PPN has a leading role in postural control in humans. In a second part, we examined the role of the cortex-basal ganglia-PPN circuit in FOG and falls in a non-parkinsonian elderly population and demonstrated a selective lesion of this circuit in these subjects. Taken together, these data support the pathophysiological hypothesis for the origin of abnormal gait and balance in patients with PD, with lesion and/or dysfunction of the cortex-BG-PPN.</div></front></TEI><affiliations><list><country><li>France</li></country></list><tree><country name="France"><noRegion><name sortKey="Demain, Adele" sort="Demain, Adele" uniqKey="Demain A" first="Adele" last="Demain">Adele Demain</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000755 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000755 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Hal:tel-01372198
|texte= Role of subthalamic nucleus and pedunculopontine nucleus in gait and balance in humans
}}
| This area was generated with Dilib version V0.6.29. |  |